Hunting vigorously through the lazylaces archives for "point'n'click" unearthed the following results...
The Lost Trio need help escaping from the old castle. Can you help the 3 of them help each other to escape? [subbed by Selfdefiant].
Aye Caramba! Can you find all the items, and solve the riddles, in Tanooky Tracks to help Alfa & Max remove all of the Tanookies from their home? [subbed by Myuhinny, f00 & subzero].
Banner Escape is a small & cute escape game hidden (in plain sight) in the title banner of the linked page. Note that it also shares its space with another game 50% of the time, so if you get a different game at the top of the page (tower of chicks game) just keep refreshing the page until the title banner looks more like part of the screenshot above [subbed by subzero].
Wild West Escape is set in the not so wild bit of the west where they had street lighting installed... [subbed by Myuhinny].
Rat Of Hamelin 5 should do the trick...
Abandoned V we ponder what the 22nd letter of the alphabet could have done to make the other 25 letters turn their backs on it... [subbed by Selfdefiant].
Ice Cave Room Escape by collecting rabbits.... It doesn't really make sense, but then again neither did Vanilla Ice [subbed by fiona & f00].
Green Room has been hand crafted from nuggets of the purest green for your entertainment, delight and escaping pleasure [subbed by fiona].
deerstalker hat, amusingly shaped pipe and a passing Watson, as I do declare, "The game is afoot!" in Sherlock Holmes Secret [subbed by Sarah].
Indiana Jones Warehouse Escape is either a very disappointing 5th film in the Indy franchise (the picture doesn't move, and there's no Harrison) or it's a point'n'click game of questionable quality, you decide... [subbed by Dov].
Deep Chalk series was out, so I couldn't resist quickly grabbing a passing interweb tube to post Deep Chalk 4. Enjoy. Now, I'm off, not that I was ever here, say no more... [found via bontegames].